Cardinal Health, Nationwide, AEP, Huntington, and data-center specialist Vertiv represent the region on Fortune’s prestigious list.
On June 2, 2025, Columbus-based outlets revealed that five Central Ohio companies secured spots on the latest Fortune 500 rankings. Headlining the list is Cardinal Health, ranked #15—a testament to the region’s deep economic roots and growing national clout.
The Fortune 500 is a benchmark of the nation’s most financially powerful corporations. Ohio boasts 28 companies on the 2025 roster, a notable presence in the Midwest. Central Ohio, in particular, is highlighted for housing major corporate headquarters that drive regional employment and innovation.
Here’s how Central Ohio’s Fortune members stack up in 2025:
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Cardinal Health (Dublin): #15 with $226.8 billion in 2024 revenue
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Nationwide (Columbus): #72, $58.6 billion
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American Electric Power (Columbus): #218, $19.7 billion
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Huntington Bancshares (Columbus): #351, $12 billion
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Vertiv Holdings (Westerville): first-time entry at #471 with $8 billion
This marks a solid showing for the region, with newcomers like Vertiv reinforcing Columbus’s status in high-tech and data-center infrastructure.
Economic & Regional Impact
- Employment booster: Fortune 500 firms are key employers across healthcare, finance, utilities, and tech sectors, underpinning Ohio’s diversified economic base.
- Growth magnet: The added prestige attracts capital, fosters innovation, and anchors corporate residency—leading to more jobs and investment.
- Strategic advantage: With national leadership in healthcare, insurance, and tech services, Central Ohio strengthens its competitive edge in attracting future talent and facilities.
